When glutamate receptors get blocked by alcohol, that can inhibit several different processes in the receiving neuron, including the release of other neurotransmitters. It also inhibits the activation of enzymes and hormones that play vital roles in almost all bodily processes.
The neuron’s ability to switch genes on and off is also impaired. Switching genes on and off is an essential bodily function. It is the only way for cells to create receptors, secrete neurotransmitters and keep themselves alive.
If these processes are disrupted, that can damage the proper functioning of your brain.